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erythromycin ethylsuccinate will raise the degree or effect of vardenafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/check carefully. Limit vardenafil dose to 5 mg/24 hr fluconazole will boost the degree or influence of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/watch careful